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For example, A42 levels tend to plateau in later disease stages, reducing their dynamic utility, while tau and NFL levels may be confounded by coexisting neurodegenerative conditions, as illustrated in Figure 2B

Spine 46 , E810E816 (2021)

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Consequently, OTUD5 DUB activity counteracts UBR5 but TRIP12 overcomes the deubiquitylation, facilitating branched chain formation and OTUD5 proteasomal degradation