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doi: 10.1038/s41598-017-11004-7 23 PedreBTalwarDBarayeuUSchillingDLuzarowskiMSokolowskiMet al

These advances collectively broaden the landscape for peptide investigation, moving toward more predictable absorption models and robust experimental reproducibility

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However, significant challenges remain, including the synthesis of stable tripeptides with good tissue penetration, insufficient understanding of their mechanisms of action, the scarcity of studies in larger animal models and human trials, and the lack of direct head-to-head comparisons with larger peptides [75, 95]

Mol Pharmacol 80:210218 [DOI] [PMC free article] [PubMed] [Google Scholar] Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT