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Gastrointestinal adverse events were the most frequently reported, but were predominantly mild to moderate

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doi:10.1172/JCI118475 39

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This suggested that the initial compound had likely degraded through hydrolysis to a sulfonic acid derivative 27 with the separate imidazole leaving group present in the mixture, a hypothesis that was confirmed by LC-MS analysis of the original compound stock (Supplementary Fig

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The injections are administered via thin needles into subcutaneous fat (e.g., upper arms, thighs, stomach) or near an injury, not into a vein

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