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therefore, the impact of the CYP3A4/5 polymorphisms could not be determined

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This is one reason bedtime dosing is common it lines up with a natural dip in somatostatin activity

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Some osteogenic markers (e.g., ALP, RUNX2, OSX and COL-I) are secreted during the early stage of osteo/odontoblastic differentiation, whereas OCN is involved in the late-stage differentiation process 30,31,32,33

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