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As a result, the use of medications like Ozempic, Wegovy, Zepbound, Rybelsus, and Mounjaro has skyrocketed, as people turned to these medications to help them lose weightcausing drug shortages and creating a market for compounded versions of these brand-name drugs

Interestingly, in a retrospective study of 186 patients (56% type 1 diabetes mellitus) from the Netherlands, dyspeptic symptoms, with the exception of early satiety and abdominal pain, were unrelated to delayed gastric emptying [69]

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Clinical trials, like the ACRC Trials Weight Loss Study, are being conducted to carefully test these new approaches and monitor their safety

Some clinicians consider adding medications from entirely different classes (e.g., naltrexone/bupropion) only after maximizing GLP-1 or GIP agonist therapy alone

doi: 10.3390/ijms23052789 93 NaravaRJabaJ