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Dietary folate deficiencies and drugs that interfere with folate metabolism, eg, methotrexate, an anti-carcinogenic agent that inhibits dihydrofolate reductase, and nitrous dioxide (N 2 O), an anesthetic gas that inhibits methionine synthase activity, lead to accumulations and cellular effluxes of homocysteine, causing increases in circulating homocysteine levels (Ueland and Refsum, 1989)

Further study on the brain injury model of mice induced by Cadmium (Cd) showed that L-theanine could protect mice from Cd-induced neurotoxicity, which was achieved by reducing the level of Cd in the brain and plasma, inhibiting the death of neurons in the cortex and hippocampus, improving the activities of SOD, GSH, and CAT in the brain, and most importantly, significantly alleviating the hyperphosphorylation of tau protein Ser199, Ser202, and Ser396 ( In addition, L-theanine could be cooperated with other substances to protect from neuro injury

15 Activation of striatal D 2 receptors inhibits GABA/enkephalin efferents (medium spiny neurons) to the globus pallidus externa

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[DOI] [PubMed] [Google Scholar] 98.Rupcic Z., Rascher M., Kanaki S., Kster R.W., Stadler M., Wittstein K