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Laboratory investigations may reveal neutropenia, elevated 3-MGA in urine, and elevated lactate in blood and cerebrospinal fluid

4 More recently, the FDA Reauthorization Act of 2017 (FDARA) made a reference encouraging the enrollment of more diverse patient populations, and the Final Rule for Clinical Trials Registration and Results Information Submission (42 CFR Part 11) went into effect in January 2017

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