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5.2 Limitations of conventional topical flavonoid delivery Although certain flavonoids such as naringenin and flavanone exhibit enhanced skin permeability under inflamed or barrier-compromised conditions, their transdermal absorption remains limited in intact skin, often necessitating the use of penetration enhancers to achieve therapeutic depth (Wang et al., 2024)

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Before extraction, milk thistles fruits contain: Silymarin Silyhermin Neo-silyhermin A and B Protein Vitamin E Sterols i A group of unsaturated steroid alcohols that occur naturally in plants and animals and play an important role in cell structure and function

Correction of riboflavin deficiency in individuals who are both riboflavin and iron deficient improves the response of iron-deficiency anemia to iron therapy (19)

10.4103/NRR.NRR-D-23-01508 118 ZitkaO.SkalickovaS.GumulecJ.MasarikM.AdamV.HubalekJ.et al (2012)