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2025;26(5):2084.[DOI] 208

C.GollowitzerA.LaoukiliJ.KranenburgO.WerzO.KoeberleA.et al (2020)

There are some areas you should not inject

28 However, oral therapy does not improve serum methylmalonic acid levels as well as intramuscular therapy, although the clinical relevance is unclear

The acute decrease in UMP/UDP/UTP levels that resolves despite continued TS inhibition supports the hypothesis that an increase in nucleotide salvage might be linked to our observed mitochondrial phenotypes