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Thus, when designing new ACTs targeting multiple parasitic pathways, it is advisable to avoid combining ARTs with agents that rely on iron utilization disruption

Ca 2+ is implicated in the regulation of neurotransmitter release from presynaptic nervous terminals

Inhibition of protein synthesis rescues both mTORC1 signaling and the ISR during cystine starvation Protein synthesis takes precedence over other cysteine-consuming pathways under normal and particularly under sulfur-deficient conditions 22

Gastrointestinal disorder biomarkers

These changes include an increased expression of liver de novo serine synthesis pathway enzyme, PSAT1, which is among the most reproducible responses to dietary SAAR (2

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