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A diabetes medication has become so popular over the internet as a weight loss supplement that doctors are concerned it will be unavailable for patients who really need it

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Combination with sulfonylureas similarly requires dose reduction or discontinuation due to hypoglycemia risk

It could also be due to the adipocyte dysfunction linked to low vitamin B12 levels through cellular inflammation

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Biochem J 474:877883 Foyer CH, Souriau N, Perret S, Lelandais M, Kunert KJ, Pruvost C, Jouanin L (1995) Overexpression of glutathione reductase but not glutathione synthetase leads to increases in antioxidant capacity and resistance to photoinhibition in poplar trees