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Trivedi, B
The reason route of administration matters so much with this class of drug comes down to basic pharmacology
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However, it is still a direct myocardial depressant (reduces contractility), and in states in which the sympathetic nervous system is already highly activated (e.g., cardiogenic shock), ketamine retains potential for inducing hypotension
JanulewiczPAKrengelMHMauleAWhiteRFCirilloJSissonEet al
Nicu C, O'Sullivan JDB, Ramos R, Timperi L, Lai T, Farjo N
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