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Parameters were breathing frequency (fr), tidal volume (Vt), minute ventilation (Ve), inspiratory time (Ti), expiratory time (Te), peak inspiratory (PIF) and peak expiratory (PIF) flows

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Sirtuins are a family of enzymes that deacetylate proteins , removing acetyl groups from lysines on histones (which regulates gene expression) and on other proteins (which regulates metabolism and stress response)