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doi: 10.1038/ncb1101-1009

Topical copper peptides primarily affect the epidermis and upper dermis, where penetration allows direct delivery

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A favorable effect was noticed on the level of IL-6 and IGF-1, but this effect did not reach a significant level

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At the level of inflammatory tissue, bromelain reduces vasodilation, and increased capillary permeability, leukocyte migration and local pain by inhibiting the formation of bradykinin and serotonin