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Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration

BPC-157 is a 15-amino-acid fragment associated with angiogenic signaling. TB-500 is a thymosin beta-4 fragment associated with repair-cell movement. Their proposed roles are complementary, not interchangeable

Furthermore, all experiments were carried out under a blind protocol, and the effects were assessed by examiners who were completely unaware of the protocol

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PMCID: PMC11890406