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However, those models used in reproductive toxicology based on QSAR methodology to estimate the extent of transfer of xenobiotics may not always be so reliable since they accept that the transport of drugs and chemicals through the placental barrier occurs only by passive diffusion and not by active transport [102,103,104,105,106,107,136,137]

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Inactivation of the second allele of tumor suppressor genes would be an early event in this oncogenic pathway

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This approach significantly improves bioavailability over standard oral glutathione forms