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GH Insensitivity Syndrome Collaborative Group

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After 12 days of treatment, mice were sacrificed, and brains were collected as described above and stored at 80 C for downstream analyses

Despite the limited data from human trials, current studies have focused on specific molecular mechanisms and used representative animal models of PD

While GTs initiate extracellular GSH breakdown, the primary intracellular degradation pathway is now thought to be mediated by the cationic transport regulator homolog (ChaC)-like family of -glutamylcyclotransferases (GCT) ( ChaC-like family proteins are remarkably conserved, being found across all phyla from bacteria to humans, where they catalyze intracellular GSH degradation and yield 5-oxoproline and cysteinylglycine (Figure 2)