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Note: All extraction reagents were pre-cooled at -20C before use

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Tri-Luma cream containing hydroquinone 4%, tretinoin 0.05%, and fluocinolone acetonide 0.1% has been authorized by the FDA for melasma management and should be applied once daily on the affected facial areas for at least 8 weeks (Spierings, 2020)

2.2.2 Effects of blue light on the retina Research has shown that the mechanism of retinal blue light damage is mainly related to the production of free radicals, lipid peroxidation, lipofuscin, rhodopsin, Ca 2+ levels, and other factors