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Safety & side effects Common side effects The most common side effects are gastrointestinal, nausea, diarrhea, vomiting, and constipation, usually mild to moderate and most likely while your dose is being increased

Studies suggest that these newer potassium binders allow patients to remain on RAASis in the treatment of chronic kidney disease and heart failure.[33,34] Consequences of discontinuing guideline-directed medical therapies RAASis and MRAs are both key disease-modifying agents for treating chronic kidney disease, cardiovascular disease, and diabetes mellitus.[35-37] They lead to increases in potassium concentration due to their interference with aldosterone (indirect and direct blockade), thus impairing excretion by the kidney

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Women of childbearing potential should use effective contraception, and the medication should be discontinued at least 2 months before a planned pregnancy

The cream is typically applied twice daily, and the effects can usually be observed within a few days of consistent use