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Studies using exogenous GLP-1 infusion in humans demonstrated reduced energy intake, reduced appetite and decreased brain responses to food anticipation and consumption without direct changes in energy expenditure, and data strongly suggest that body-weight loss ensuing from GLP-1R agonist administration in humans largely reflects reductions in food intake [24, 25]

doi: 10.1001/jamainternmed.2013.2720 61 NoelRABraunDKPattersonREBloomgrenGL