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Arch Gerontol Geriatr 46:181190 Malaguarnera M, Vacante M, Bertino G, Neri S, Malaguarnera M, Gargante MP, Motta M, Lupo L, Chisari G, Bruno CM, Pennisi G, Bella R (2011) The supplementation of acetyl-l-carnitine decreases fatigue and increases quality of life in patients with hepatitis c treated with pegylated interferon-alpha 2B plus ribavirin

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In some embodiments, the otic formulation or composition comprises about 0.3% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

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