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Excess histamine stimulates the sympathetic nervous system, increasing heart rate and driving anxiety

Alcohol, pancreatitis, and GLP-1 risk Alcohol is one of the leading causes of acute and chronic pancreatitis

Impairment of Fertility No nonclinical fertility studies have been conducted with codeine or the combination of codeine and acetaminophen

GLP-1 receptor agonists should be avoided in patients with a history of medullary thyroid cancer or MEN2

This is a theoretical risk not yet documented in KLOW-specific literature, but it's mechanistically plausible enough to warrant immediate investigation if symptoms appear

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