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If you have a deficiency in the G6PD enzyme, it can be unsafe to administer doses of Vitamin C above 10g

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The consistent theme is restraint: hold the per-dose amount steady, use frequency and cycle structure as the adjustable variables, and build in breaks

Eventually, the signaling pathway between the brain and the adrenals can become impaired, and the person will underproduce cortisol

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EGCG also modulates key apoptotic regulators, such as Bcl-2 family proteins, increasing anti-apoptotic expression while regulating pro-apoptotic proteins under normal physiological conditions [71]