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This paper demonstrates the advantages of direct reprogramming of ALS patient fibroblasts, via induced neural progenitor cells, into astrocytes, which are toxic to motor neurons in coculture and are non-clonal and retain the epigenetic features of ageing

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Patients with bad living habits such as smoking and excessive alcohol consumption, those suffering from diseases such as hypertension and diabetes, as well as those who are obese (with a BMI 28) were excluded from this study

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