once-weekly semaglutide in adults with alcohol use disorder RCT: reduces craving and consumption - Knopf - 2025 - Alcoholism & Drug Abuse Weekly Associations of semaglutide with incidence

In the SOUL study, significant improvements in HbA1c, systolic blood pressure, weight, and high-sensitivity C-reactive protein were also found

You Need a Higher Dose You may need a higher dose of a GLP-1 (or any other medication, for that matter) in order to achieve the results youre seeking, even if youve made the recommended lifestyle changes

Some of these patients may be switching to a different GLP-1 receptor agonist, which may occur for several reasons, but practical guidance on how to safely and effectively manage such a transition is scarce

The drug is prescribed under several brand names, including Wegovy, Ozempic, and Rybelsus

Even at lower doses, GLP-1s carry risks of gastrointestinal issues, including nausea, constipation, and general abdominal discomfort

Notably, patients with reduced ejection fraction had higher absolute event rates, meaning the medication prevented more events in this higher-risk group