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This triple-agonist approach, targeting GLP-1, GIP, and glucagon receptors, produced the most dramatic weight loss results seen in any Phase 2 obesity trial

The removal of this region and the multivalent presentation on a ferritin nanoparticle significantly improved DCFHPs neutralizing potency in mice relative to the use of unedited spike, since it allows the immune system to not get distracted by creating an antibody response against a region that is ultimately nonneutralizing [134]