The KTTKS sequence is derived from the C-terminal propeptide of type I procollagen and acts as a matrikine -- a peptide fragment that signals cells to produce new extracellular matrix components
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Its synthetic form, used in laboratories worldwide, has been the subject of extensive scientific interest across fields such as: tissue regeneration studies cellular repair models angiogenesis (blood vessel formation) analysis inflammatory response mapping organ-system protection research musculoskeletal recovery pathways oxidative stress reduction studies Because the peptide exhibits strong biological signalling potential, it has become one of the most widely analysed peptides in performance-science and biomedical research
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Funding This work was supported by the Postdoctoral Innovation Practice Base of the First Affiliated Hospital of Nanchang University (grant 338937), the Jiangxi Provincial Young Talents Project (grant 20204BCJ23016), the National Natural Science Foundation of China (grants 82202869, 82260491, 82160459, 82160469,82360584), the Jiangxi Province Double Thousand Program (grant jxsq2023201108), Key Projects of Jiangxi Province (grant 20232ACB206044), the Science and Technology Department of Jiangxi Province (grant 20202BABL216050), and the Jiangxi Provincial Natural Science Foundation (grant 20232BAB216087 and 20224BAB216008)
