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Intracellular G-protein-coupled receptors, particularly the trace amine-associated receptor 1 (TAAR1), function as internal sensors of cytoplasmic catecholamines and their metabolites (Underhill et al., 2021)

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frequent administration within short periods may decrease patient tolerance, while prolonged intervals might provide tumor cells with opportunities for regrowth (121)

Specifically, under energy stress, intestinal Bifidobacterium pseudolongum -upregulated Cr production activates the AMP-activated protein kinase (AMPK) pathway, suppressing ionizing radiation-induced PUFA synthesis and thereby counteracting ionizing radiation-associated ferroptosis progression (He Y

The study was retrospective, relied on structured EHR data, and used coded definitions for recurrence rather than centrally adjudicated oncologic outcomes

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