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Abbreviations COVID-19, coronavirus disease 2019

Sanyal AJ, Chalasani N, Kowdley KV, et al

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Protein structure comparison showed that SsCm1 was obviously different from other Cms in three-dimensional structure, and molecular docking simulation revealed that SsCm1 showed less affinity with chorismate (binding energy = 2.1 kcal/mol) than ScAro7 (5.7 kcal/mol) (Supplementary Fig

As such, niclosamide can inhibit virus replication as demonstrated in Vero 6 cells at only 1M (10) and has also been shown to have similar anti-replicative efficacy in cultured Calu-3 lung cells, at 2M (34)