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28 Half-Life and Steady State If the dose of a drug that is administered is greater than the dose that is eliminated during the dosing interval, it will take about 5 half-lives for a drug to reach steady state levels

But the doses used in fertility studies (especially for men) are usually in the 1,000-3,000 mg per day range

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10.1053/j.gastro.2013.10.052 Gastroenterology 120 PanaccioneR.GhoshS.MiddletonS.VelazquezJ

Additionally, a randomized controlled trial found that isoflavone-based supplements improved sleep quality and reduced insomnia symptoms in postmenopausal women, further supporting a strong link between antioxidant supplementation and improved sleep outcomes (Mondul et al., 2011