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Under these conditions, mitochondrial dysfunction will compromise metabolic performance in association with increased reactive oxygen species (ROS) generation

If morning injection causes you so much nausea that you skip meals, miss workouts, or dread injection day, the metabolic costs of that stress and disruption far outweigh any circadian benefit

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[2] [3] Hormonal and metabolic factors can also interfere with appetite regulation

Lee, Jun-Kyoung, et al

Simic, T., Pljesa-Ercegovac, M., Savic-Radojevic, A., Hadziahmetovic, M