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It means there is no established data on how these peptides behave in human pharmacokinetics, what adverse events occur at what frequencies, or what drug interactions are possible

According to the NewcastleOttawa Scale (NOS) for case-control studies (n = 2) (Yamane et al., 1995

Retrieved March 20, 2018

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First, aggregated peptide cannot bind to receptors properly, reducing or eliminating the therapeutic effect

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