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Evidence from animal and human studies shows that B 12 also has neuroprotective and anti-inflammatory properties,15 and intervention studies in humans have reported beneficial effects of better B 12 status or B 12 therapy in multiple sclerosis,16 Parkinsons disease,17 myalgic encephalomyelitis,18 autism,19 and (administering very high doses of methylcobalamin) in amyotrophic lateral sclerosis.20 Subcutaneous administration is sometimes recommended when intramuscular injections are contraindicated, for instance, in people using anticoagulants

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On the other hand, those with severe kidney problems taking high amounts of B12 may see a high level of toxicity since the excess vitamin B12 wont get eliminated from the body easily