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A: Retatrutide peptide is a triple receptor agonist (GLP-1/GIP/Glucagon), while semaglutide is single receptor (GLP-1) and tirzepatide is dual receptor (GLP-1/GIP)

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Individuals with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN2) are commonly excluded from trials of GLP-1 receptor agonists as a precautionary measure