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doi: 10.3389/fnut.2022.1036080 Received 03 September 2022 Accepted 30 September 2022 Published 26 October 2022 Volume 9 - 2022 Edited by Carlos Gmez-Gallego, University of Eastern Finland, Finland Reviewed by Iman Zarei, University of Eastern Finland, Finland

Int J Pharm 386(1):262267 Zhong L, DUrso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

So even if resM tripled your natural GLP-1 production, the cumulative receptor activation would still be a fraction of what a standard tirzepatide dose achieves

Without enough of it, fatty acids cant effectively enter the mitochondria, and instead of being burned off, fat can accumulate

Any and all questions I had were answered and explained well