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Medications included other noninsulin, non-GLP-1RA glucose-lowering agents, antihypertensive drugs, statins, non-GLP-1RA anti-obesity medications (that is, orlistat, phenterminetopiramate, naltrexonebupropion, diethylpropion, phentermine and benzphetamine), corticosteroids, antipsychotics and antidepressants
It also modulates nitric oxide signaling, which regulates blood flow and inflammatory responses
It may also regulate the production and release of significant hormones and neurotransmitters like melatonin and growth hormone
It may prevent the binding of the FOXO4 protein with p53, allowing p53 to bind with DNA and trigger apoptosis in senescent cells
Pantoja JL, Defilippi C, Valenzuela JE, Csendes A
A.McArthurD
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