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TB-500, while sharing these actin-related effects, remains particularly useful for studying local cytoskeletal behavior in isolation

10.1128/AAC.45.3.715-722.2001

Clinical use in humans is based on extrapolation from preclinical data, clinical experience, and case reports

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Because controlled safety studies are lacking, glycine injections are used during pregnancy or lactation only when potential benefits clearly outweigh unknown risks.Discuss thoroughly with your obstetric or pediatric provider

This distinction is crucial: most fundamental studies on the actin mechanism focus on the entire T4, and extrapolation to the TB-500 fragment alone remains incomplete in the published literature