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3 The study authors state that deficiency of some isoforms of carnitine, especially those esterified with short-chain fatty acids, may play an important role in cardiac involvement in course of IBD and could lead, over time, to dilated cardiomyopathy. Chronic Fatigue Syndrome and L-Carnitine Deficiency Apparently, just taking omega-3 fatty acids can improve the effects of the L-carnitine you already have in your body and when taken with L-carnitine are further enhanced