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Campbell P, Iapoce C

Most patients experience a reduction in appetite, which helps them make healthier food choices and may contribute to gradual weight loss

That is significantly more than the roughly 15% achieved with semaglutide at its highest dose in comparable trials

Tetramerization forces the N-terminal threading arms from the arm-exchanged dimer to cover the heme active site for the other pair of dimers and suggests that catalase fits the more general pattern of domain swapping with the arm-exchange being a later, tetramer-dependent elaboration