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Bone health A study published in the Journal of Bone and Mineral Research (5) found that low B-12 was linked with poor bone mineral density, suggesting a role for the vitamin in bone formation

Similarly, Section 503B does not allow for compounding of drugs that are essentially a copy of one or more approved drugs but the statute notes that this does not apply to drugs on the drug shortage list in effect under Section 506E. The 506E shortage list recognizes drugs that have low availability due to manufacturing or quality problems, delays or discontinuations

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However, in some cases the effects may be clinically significant since antibodies may activate complement causing haemolysis, or the agglutinated cells can cause occlusion of small blood vessels in the cold (acrocyanosis)