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Both are noncompetitive inhibitors, altering the Vmax while the Km for substrates remains constant

It has moderate bioavailability but a relatively long half-life (~ 610 h), which supports its sustained anti-inflammatory effects

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"The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations"