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Introduction of 7o8G-miR-1 alone could induce cardiac hypertrophy in mice, while specific inhibition of 7o8G-miR-1 alleviated the hypertrophy, suggesting that oxidative modifications of miR-1 induced by oxidative stress could serve as potential biomarkers and therapeutic targets

They occur during the developmental process in the womb

Obesity treatment guidelines emphasize a stepwise approach, focusing initially on evidence-based nutrition and lifestyle modifications centred on hypocaloric dietary patterns and physical activity regimens, tailored to individual needs, followed by escalation to pharmacotherapy and bariatric surgery [[4], [5], [6], [7]]

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