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Introduction The increasing prevalence of type 2 diabetes mellitus (T2DM) and obesity highlights the urgent clinical need for pharmacotherapies with substantial weight loss and optimal glycemic control ( Semaglutide is a GLP-1 RA that has shown significant clinical advantages in both diabetic and non-diabetic populations
Topiramate may reduce appetite through its effect on GABA receptors [20]
The full weight loss benefits typically emerge after reaching the maintenance dose (2.4 mg for Wegovy) and continuing treatment for several months
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