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Extracellular GS-Es are degraded sequentially by cell surface enzymes, -glutamyl transpeptidase (GGT) and dipeptidases, to cysteinyl-electrophile conjugates that are N-acetylated to mercapturic acid in the kidneys

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The spectrum of dermatoses observed included melasma ( n = 46), LPP ( n = 22), acanthosis nigricans ( n = 6), Beckers nevus ( n = 9), caf-au-lait macules (CALM) ( n = 5), exogenous ochronosis ( n = 8), macular amyloidosis ( n = 13), lichen amyloidosis, periorbital hyperpigmentation ( n = 18), Riehls melanosis ( n = 3), pigmented purpuric dermatoses ( n = 4), seborrheic melanosis, seborrheic keratosis ( n = 4),freckles, DowlingDegos disease (DDD), terra firma-forme dermatosis (TFFD), and melanocytic lesions including nevus of Ota ( n = 4), Mongolian spot ( n = 2), and lentigines ( n = 2)