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The cardiovascular benefits of GLP-1RAs are well-established, with clinical trials demonstrating reductions in major adverse cardiovascular events (MACE), improved endothelial function, and lower blood pressure

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79 GLP-1 receptor agonists are located throughout the brainstem and hypothalamus

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Melatonin protects against PM 2.5 -induced lung injury by inhibiting ferroptosis of lung epithelial cells in a Nrf2-dependent manner