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Many POTS patients claim heat intolerance and this may be mediated by unopposed glutamate [64]

Both have intriguing preclinical profiles but very limited human clinical data

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12.2.2 Potential antagonistic effects Conversely, curcumin has been shown to interfere with the action of other chemotherapeutic drugs (e.g., cyclophosphamide, doxorubicin) by activating certain detoxification pathways (like ABC transporters) that pump the drugs out of cancer cells, thereby reducing their effectiveness (244)

[40], which indicates that sugar-enriched diets impair endogenous antioxidant defenses and exacerbate oxidative injury