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In sequence terms, that Cterminal block is exactly the kind of motif that enables membrane penetration, The region: ArgArgSerGlyGlyLysArgProProProArgArgArgGlnArgArgLysLysArgGlyOH` has all the hallmarks of a CPP: High local positive charge density Arginine is the key driver the guanidinium group forms bidentate hydrogen bonds with phosphate and sulfate groups on the cell surface (heparan sulfate proteoglycans, phospholipid headgroups)

DOI:10.4049/jimmunol.170.11.5583 7.Christophers.E, Henseler.T, Contrasting disease patterns in psoriasis and atopic dermatitis

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