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2021;33(4):e2002047

As OTS964 treatment results not only in SF3B1 dephosphorylation, but also in stalling of spliceosome in B OTS964 intermediate, it is very likely that conformational change of the spliceosome itself also contributes to the observed decrease of P-SF3B1 binding to the ISL in U6 snRNA and we cannot distinguish between these two scenarios

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IGF-1 levels should be interpreted against age- and sex-adjusted reference ranges, with the goal of supporting physiologicalrather than supraphysiologicconcentrations

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The bottom Percoll fraction contained non-infected RBCs and approximately 1520% rings, morphologically identical to those of the ring-enriched fraction