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The downstream effects include activation of hormone-sensitive lipase in adipose tissue (which breaks down stored triglycerides into free fatty acids), increased protein synthesis in skeletal muscle, enhanced cellular repair and turnover, elevated IGF-1 production from the liver, and improved lipid metabolism including reduced triglycerides

Specific alleles (e.g., DRB103:01, DRB104:01, DQA105:01-DQB102:01 [DQ2], DQA103:01-DQB103:02 [DQ8]) confer elevated risk by determining the efficiency and specificity of autoantigen presentation to CD4 + T cells [63,64,65,66]

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These studies showed a possible link to thyroid C-cell tumors in rodents

In clinical trials, retatrutide has been studied as a onceweekly injection