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When combined with the exclusion of patients with either acute or chronic pancreatitis from prior clinical trials, this observation aligns with the caution raised by the American Diabetes Association to avoid use of GLP-1RAs for patients with any history of acute or chronic pancreatitis 27

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Cardiac and Renal Considerations Due to the glucagon component, some participants experienced a transient increase in heart rate during the first few months of treatment

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